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KMID : 0378019780210090093
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New Medical Journal
1978 Volume.21 No. 9 p.93 ~ p.97
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Effect of Ethyl Alcohol on Water Metabolism and ADH in Man
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Abstract
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The possibility that ethanol inhibits release of antidiuretic hormone (ADH) from neurohypophysis and thus produces a diuresis was examined in 20 healthy men. A control and an alcohol experiments were performed in each subject. Alcohol drink was consisted of 1..5 ml of 100 proof vodka (0.6g) /kg body weight, diluted to a constant -volume of 250 ml with orange juice. Following results were obtained.
1. Alcohol produced more than 4-fold increase in urine flow during the second hour. The
diuresis was disappeared there after.
2. Urinary excretion rate of ADH began to decrease 1 hour after alcohol ingestion, decreased to 55% of the predrinking level at the second hour and returned to the control level at the third hour.
3.The alcohol diuresis was due neither to an elevated glomerular filtration rate (GFR) nor to an increased osmolar excretion. Markedly elevated free water clearance indicates the inhibition of renal tubular water reabsorption during the diuresis.
4. Water ingestion did not alter urine flow, urinary ADH excretion, GFR, osmolar or free water clearance.
5. The finding supports the hypothesis that the diuresis produced by alcohol is mediated at least in part by a reduction in release of ADH. However, a possibility that alcohol has a direct effect on the renal tubule to inhibit the water reabsorption is remained unclear.
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